Patrick DeGuire started his career in stand-up after losing a significant amount of his vision because of an eye disease called optic neuritis. Soon after being diagnosed, Patrick discovered laughter as a means of self therapy. Soon after getting started, Patrick won the 1998 Improv/Harrahs National Comedy Club Talent Search. Credits include national television appearance on Comedy Central, 'Que Loco' on Galavision, 'Loco Comedy Jam' on Telemundo among others.

Patrick has also toured with George Lopez, Paul Rodriguez and Tommy Davidson. Besides performing at the top comedy clubs in the United States, Patrick has also performed for the troops overseas in Japan and Korea. Patrick's material includes the advantages and disadvantages of living in a world with limited vision and the complications that arise from it. Patrick discusses the obstacles of relationships and marriage and raising four children. Patrick addresses an assortment of other topics that are insightful and hilarious.